Current animal-based safety assessment is too slow and costly for industry and regulators to test all nano-sized materials entering the market and environment.
Exposure
3-6 months
Adverse outcome
The EU-funded nanoPASS project will design new screening approaches for inhalation hazards based on early key events that lead to adverse outcomes.
Exposure
1 week
Prediction of adverse outcome
Prediction of 4 adverse outcomes related to inhalation of particulate matter:
Jožef Stefan Institute is the leading Slovenian research organisation. It is responsible for a broad spectrum of basic and applied research in the fields of natural sciences and technology. In Laboratory of Biophysics, we are responsible for quantitative detection of dynamics of early key events in vitro with advanced optical microscopy methods, and for development of new in vitro models.
Role in the project:
Quantitative detection of dynamics of early key events with in vitro high-resolution & high-throughput advanced optical microscopy methods and development of new in vitro models.
Infinite is a research - focused biotech spin-out from the Jožef Stefan Institute and a leading developer of predictive toxicology technology based on in vitro molecular event quantification and in silico time propagation.
Role in the project:
Infinite is responsible for developing animal test alternatives for chronic lung inflammation utilizing predictive toxicology technology.
Helmholtz Munich develops solutions for a healthier future.
Role in the project:
Identification of early key events with in vivo intravital microscopy
The National Research Centre for the Working Environment (NFA) is a government research institute under the Danish Ministry of Employment which conducts research at the highest international level to:
Role in the project:
STAMI is the National Institute of Occupational Health in Norway. It is responsible for providing research-base knowledge on the Norwegian working life in order to prevent illness and promote good health among workers.
Role in the project:
Development of in vitro and in silico models, providing industrial test nanomaterials.
National University of Ireland, University College Dublin
Role in the project:
In silico characterisation of nanomaterials, development of models for prediction of nanomaterial toxicity.
The Nanotechnology Industries Association (NIA) is the cross-sectoral, responsible voice for nanotechnology value chains and the global commercial eco-system.
Alpacem is the biggest Slovenian cement producer.
Role in the project:
Alpacem – Industrial partner, provide access to the facility, decide collection locations in the production line for collection of industrial nano materials.
